%0 Figure %A W. Winkler, Thomas %A Brandl, Caroline %A Grassmann, Felix %A Gorski, Mathias %A Stark, Klaus %A Loss, Julika %A H. F. Weber, Bernhard %A M. Heid, Iris %D 2018 %T Manhattan and QQ plot of joint age-stratified 2df P-values. %U https://plos.figshare.com/articles/figure/Manhattan_and_QQ_plot_of_joint_age-stratified_2df_P-values_/5974903 %R 10.1371/journal.pone.0194321.g002 %2 https://ndownloader.figshare.com/files/10719727 %K loci Late-stage age-related macular degeneration %K non-modifiable risk factors %K AMD loci %K sex-stratified genome-wide association study %K novel AMD GWAS locus %K CLUL %K IAMDGC %K genome-wide interaction study %K RLBP %K ARMS %K retinaldehyde binding protein 1 %K International Age-related Macular Degeneration Genomics Consortium %K CFH %X

Shown are the age-joint P-Values (PAgejoint) for late AMD by their position on the genome (Manhattan plot) as well as their distribution (QQ plot). In the Manhattan plot, the 34 known genetic regions identified by Fritsche et al [13] are colored blue and additional genome-wide significant signals are colored red. The QQ plot shows the distribution of PAgejoint including all variants (black) as well as after exclusion of known loci (34 variants +/-500kb, red).

%I PLOS ONE