%0 Figure %A Pablo, Michael %A Ramirez, Samuel A. %A C. Elston, Timothy %D 2018 %T Computational modeling schematics. %U https://plos.figshare.com/articles/figure/Computational_modeling_schematics_/5973166 %R 10.1371/journal.pcbi.1006016.g001 %2 https://ndownloader.figshare.com/files/10829303 %K polarity establishment %K membrane %K fluctuations speed polarity establishment %K macroscopic rate constants %K reaction-diffusion equation simulations %K Turing pattern formation Polarity establishment %K Cdc 42 abundances %K particle-based simulations %K yeast polarity establishment %K yeast polarization %K molecule %K Rho GTPase Cdc 42 %K model %X

(A) Molecules at the cell membrane and a thin slice of adjacent cytoplasm are simulated explicitly. Both compartments are modeled as 2D surface. (B) In the quasi-3D simulations, a well-stirred compartment representing bulk cytoplasm is added to approximate 3D effects. (C) Reaction scheme for a Turing-type model of Cdc42-dependent yeast polarity establishment from Goryachev and Polkhilko [4].

%I PLOS Computational Biology