10.1371/journal.pone.0002954.g003
Paul E. Makidon
Paul E.
Makidon
Anna U. Bielinska
Anna U.
Bielinska
Shraddha S. Nigavekar
Shraddha
S. Nigavekar
Katarzyna W. Janczak
Katarzyna
W. Janczak
Jessica Knowlton
Jessica
Knowlton
Alison J. Scott
Alison
J. Scott
Nicholas Mank
Nicholas
Mank
Zhengyi Cao
Zhengyi
Cao
Sivaprakash Rathinavelu
Sivaprakash
Rathinavelu
Michael R. Beer
Michael
R. Beer
J. Erby Wilkinson
J.
Erby Wilkinson
Luz P. Blanco
Luz
P. Blanco
Jeffrey J. Landers
Jeffrey
J. Landers
James R. Baker Jr
James
R. Baker Jr
Development of IgG response in serum.
Public Library of Science
2013
igg
2013-02-21 09:46:20
Figure
https://plos.figshare.com/articles/figure/_Development_of_IgG_response_in_serum_/594684
<p>Effect of NE adjuvant: Mice were immunized intranasally with HBsAg-NE consisting of 20 μg of HBsAg mixed with 0% to 40% concentrations of NE (A). Significant statistical difference with <i>p value<0.05</i> was observed between all HBsAg-NE formulations and HBsAg-PBS vaccine. Antigen dose escalation: Mice were immunized intranasally with 1 μg to 40 μg HBsAg mixed with 20% NE (B). A significant statistical difference with <i>p value<0.05</i> was observed between all 5 μg to 40 μg HBsAg-NE formulations and 1 μg HBsAg-NE vaccine. Serum anti-HBsAg IgG antibody concentrations are presented as mean of endpoint titers in individual sera +/− SEM. * indicates a statistical difference (<i>p value<0.05</i>) in the anti-HBsAg IgG titers. Arrows indicate vaccine administration.</p>