%0 Figure %A Shi, Yanlin %A Xu, Qilong %A V. Seemanaplli, Sunita %A McShan, Kristy %A Ting Liang, Fang %D 2008 %T Strong humoral responses cannot effectively target the dbpAB mutant overproducing DbpA or DbpB in chronically infected mice. %U https://plos.figshare.com/articles/figure/_Strong_humoral_responses_cannot_effectively_target_the_dbpAB_mutant_overproducing_DbpA_or_DbpB_in_chronically_infected_mice_/590066 %R 10.1371/journal.pone.0003340.g003 %2 https://ndownloader.figshare.com/files/919620 %K humoral %K responses %K cannot %K mutant %K overproducing %K dbpa %K dbpb %K chronically %K infected %X

Subgroups of four or five BALB/c mice each received one single intradermal/subcutaneous injection of 105 spirochetes of the clone ΔdbpAB/dbpAB/1, ΔdbpAB/dbpAB/2, ΔdbpAB/dbpA'/1, ΔdbpAB/dbpA'/2, ΔdbpAB/dbpB'/1 or ΔdbpAB/dbpB'/2, and euthanized 4 months later. DNA samples were prepared from samples with a positive culture and analyzed for spirochetal flaB and murine actin DNA copies by qPCR. The data are expressed as spirochete numbers per 106 host cells and presented in three groups by combining the subgroups ΔdbpAB/dbpAB/1 and ΔdbpAB/dbpAB/2, ΔdbpAB/dbpA'/1 and ΔdbpAB/dbpA'/2, and ΔdbpAB/dbpB'/1 and ΔdbpAB/dbpB'/2.

%I PLOS ONE