Expression-QTNs are under-represented in coding sequence introns, even after controlling for position effects.
Jean-Baptiste Veyrieras
Sridhar Kudaravalli
Su Yeon Kim
Emmanouil T. Dermitzakis
Yoav Gilad
Matthew Stephens
Jonathan K. Pritchard
10.1371/journal.pgen.1000214.g005
https://plos.figshare.com/articles/figure/_Expression_QTNs_are_under_represented_in_coding_sequence_introns_even_after_controlling_for_position_effects_/590063
<p>The plot shows the odds ratios for the probability that a SNP in a particular part of the gene (e.g., coding exon) is inferred to be an eQTN, relative to that probability for a SNP in an “internal” intron (i.e., an intron within the coding sequence). The odds ratios are estimated using the hierarchical model with internal introns fixed at a value of 1, and control for SNP position using the TSS+TES model. The vertical bars show 95% confidence intervals.</p>
2008-10-10 00:01:03
under-represented
coding
controlling