10.1021/acs.orglett.8b00221.s001
Weiwei Jin
Weiwei
Jin
Yulu Zhou
Yulu
Zhou
Ying Zhao
Ying
Zhao
Qianqian Ma
Qianqian
Ma
Lichun Kong
Lichun
Kong
Gangguo Zhu
Gangguo
Zhu
Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes
Initiated by Radical Alkylation with Tertiary α‑Carbonyl
Alkyl Bromides
American Chemical Society
2018
Bromide
nickel catalysis
arylation
Radical Alkylation
group compatibility
Preliminary
Nickel-Catalyzed Remote Arylation
quaternary carbon center
combination
novel nickel-catalyzed
realization
alkenyl aldehydes
α- carbonyl alkyl bromides
Carbonyl
Alkenyl Aldehydes Initiated
yield
alkyl radicals
ketone
alkylation
Tertiary
bond
2018-02-12 21:09:08
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Nickel-Catalyzed_Remote_Arylation_of_Alkenyl_Aldehydes_Initiated_by_Radical_Alkylation_with_Tertiary_Carbonyl_Alkyl_Bromides/5881042
A novel nickel-catalyzed remote arylation
of alkenyl aldehydes triggered by radical alkylation with tertiary
α-carbonyl alkyl bromides is described, thus producing a quaternary
carbon center containing ketones in promising yields with broad functional
group compatibility. Preliminary mechanistic studies suggest that
the combination of a 1,<i>n</i>-HAT (<i>n</i> =
5 or 6) from alkyl radicals to aldehyde C–H bonds with nickel
catalysis may account for the realization of this reaction.