10.1021/acs.orglett.8b00221.s001 Weiwei Jin Weiwei Jin Yulu Zhou Yulu Zhou Ying Zhao Ying Zhao Qianqian Ma Qianqian Ma Lichun Kong Lichun Kong Gangguo Zhu Gangguo Zhu Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes Initiated by Radical Alkylation with Tertiary α‑Carbonyl Alkyl Bromides American Chemical Society 2018 Bromide nickel catalysis arylation Radical Alkylation group compatibility Preliminary Nickel-Catalyzed Remote Arylation quaternary carbon center combination novel nickel-catalyzed realization alkenyl aldehydes α- carbonyl alkyl bromides Carbonyl Alkenyl Aldehydes Initiated yield alkyl radicals ketone alkylation Tertiary bond 2018-02-12 21:09:08 Journal contribution https://acs.figshare.com/articles/journal_contribution/Nickel-Catalyzed_Remote_Arylation_of_Alkenyl_Aldehydes_Initiated_by_Radical_Alkylation_with_Tertiary_Carbonyl_Alkyl_Bromides/5881042 A novel nickel-catalyzed remote arylation of alkenyl aldehydes triggered by radical alkylation with tertiary α-carbonyl alkyl bromides is described, thus producing a quaternary carbon center containing ketones in promising yields with broad functional group compatibility. Preliminary mechanistic studies suggest that the combination of a 1,<i>n</i>-HAT (<i>n</i> = 5 or 6) from alkyl radicals to aldehyde C–H bonds with nickel catalysis may account for the realization of this reaction.