TY - DATA T1 - Contribution of the gH/gL-Eph interaction to RRV infection is cell type-specific. PY - 2018/02/12 AU - Anna K. Großkopf AU - Armin Ensser AU - Frank Neipel AU - Doris Jungnickl AU - Sarah Schlagowski AU - Ronald C. Desrosiers AU - Alexander S. Hahn UR - https://plos.figshare.com/articles/figure/Contribution_of_the_gH_gL-Eph_interaction_to_RRV_infection_is_cell_type-specific_/5880820 DO - 10.1371/journal.ppat.1006912.g007 L4 - https://ndownloader.figshare.com/files/10579078 KW - Eph family receptor tyrosine kinases KW - KSHV strains KW - gH KW - protein-protein interactions KW - oncogenic virus KW - Eph-binding residues KW - Eph-binding-negative RRV mutants KW - rhesus monkey rhadinovirus KW - nonhuman primates KW - N-terminal domain KW - sequence analysis KW - RRV glycoprotein H KW - B-cell malignancies KW - log order KW - RRV gL KW - Eph family receptor-binding motif KW - entry mediators KW - Inhibition experiments KW - cell types KW - host factors KW - gL expression KW - cell type-specific use KW - Eph-interaction motif N2 - A-B Comparative infection on LEC (A) or HUVEC (B) and RF by RRV wt, RRV gH-AELAAN, and RRV ΔgL. RF and LEC or HUVEC were infected with the same inocula of the respective virus stock, and the percentage of reporter gene-positive cells as determined by flow cytometry for each dilution was plotted. C Micrograph of RF and LEC infected with the same respective inocula of wt and Eph-binding-negative RRV gH-AELAAN. D-E Comparative infection on LEC (D) or HUVEC (E) and RF by RRV wt, RRV gH-AELAAN, and RRV ΔgL as in A based on mean fluorescence intensity (MFI) as determined by flow cytometry. ***: p-value < 0.001. ER -