TY - DATA T1 - Preparations and properties of drug-eluting embolization microspheres based on modified gelatin PY - 2018/02/12 AU - Liping Zhang AU - Ming Liu AU - Tian Qi AU - Haili Zhou AU - Caihua Ni UR - https://tandf.figshare.com/articles/journal_contribution/Preparations_and_properties_of_drug-eluting_embolization_microspheres_based_on_modified_gelatin/5878627 DO - 10.6084/m9.figshare.5878627.v1 L4 - https://ndownloader.figshare.com/files/10454464 KW - Doxorubicin KW - embolic microsphere KW - gelatin KW - interventional cancer therapy KW - modification N2 - Embolization using microspheres plays an important role in interventional cancer therapy. The drug-eluting embolization microspheres were prepared via reverse suspension crosslinking of gelatin, followed by modification of the cross-linked microspheres. The microspheres displayed regular spherical shapes with size distribution ranging from 180 μm to 350 μm. The negatively charged groups (COO−) were introduced into the microspheres which could load positively charged doxorubicin with loading rates as high as 26.1% and 34.0% in 1 and 12 h, respectively. The high drug-loading rates were ascribed to ionic interaction between carboxyl groups and doxorubicin. The drug release profile showed the modified microspheres (MMS) have a sustained release manner compared with non-MMS in phosphate buffered saline (PBS). The MMS were almost completely degradated after 20 days. Cytotoxicity assay certified that the MMS were non-cytotoxic, and could be potentially used as biocompatible materials. ER -