10.6084/m9.figshare.5821626.v1 Katie A O'Brien Katie A O'Brien Ross D Pollock Ross D Pollock Mike A Stroud Mike A Stroud Rob J Lambert Rob J Lambert Alex Kumar Alex Kumar Robert A Atkinson Robert A Atkinson David A Green David A Green Ana Anton-Solanas Ana Anton-Solanas Lindsay M Edwards Lindsay M Edwards Steve D.R. Harridge Steve D.R. Harridge Dataset for: Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia. Wiley 2018 Chronic hypobaric hypoxia Acclimatisation Metabolic remodelling Physiology Systems Biology 2018-03-09 06:02:01 Dataset https://wiley.figshare.com/articles/dataset/Dataset_for_Human_physiological_and_metabolic_responses_to_an_attempted_winter_crossing_of_Antarctica_the_effects_of_prolonged_hypobaric_hypoxia_/5821626 An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high altitude exposure, elicits physiological acclimatisation mechanisms alongside metabolic remodelling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n=5, male, age 28-54 yrs) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500m. Measurements taken pre and post expedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (+ 3.6) % increase in respiratory exchange ratio measured during incremental exercise (area under curve, p>0.01, mean ±SD) and a 2.1(+ 0.8) % decrease in fat tissue (p<0.05) post expedition. This was accompanied by an 11.6 (+1.9) % increase (p>0.001) in VO2 max corrected to % lean mass post expedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in-depth characterisation of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth.