%0 Generic %A Silva, Lorena Luryann Cartaxo da %A Vergilio, Fernanda Sasaki %A Yamaguti, Diva Carvalho Collarile %A Cruz, Isabela Azevedo Nicodemos da %A Queen, Joana Angrisani Granato %D 2018 %T Yolk sac primary tumor of mediastino: a rare case in a young adult %U https://scielo.figshare.com/articles/dataset/Yolk_sac_primary_tumor_of_mediastino_a_rare_case_in_a_young_adult/5816514 %R 10.6084/m9.figshare.5816514.v1 %2 https://ndownloader.figshare.com/files/10286958 %2 https://ndownloader.figshare.com/files/10286961 %2 https://ndownloader.figshare.com/files/10286964 %2 https://ndownloader.figshare.com/files/10286970 %K Neoplasms, germ cell and embryonal %K Endodermal sinus tumor/drug therapy %K Mediastinal neoplasms %K Neoadjuvant therapy %K Case reports %X

ABSTRACT Germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). We report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. This was a 38-year-old man who was admitted to Hospital do Servidor Público Estadual “Francisco Morato de Oliveira”, complaining about dyspnea and dry cough for 1 year. The computed tomography scan of his chest revealed a large mass in the anterior mediastinum with heterogeneous enhancement to the contrast associated with pleural effusion. There were also high serum levels of alpha-fetoprotein. After neoadjuvant chemotherapy, the patient underwent surgical resection of the mass, followed by pathological examination, which confirmed a primary mediastinal yolk sac tumor, a nonseminomatous subtype of germ cell tumors. Primary mediastinal yolk sac tumors have poor prognosis, despite advances in therapy with surgical resection and cisplatin-based chemotherapy. This poor prognosis is due to the degree of invasion and unresectability in most patients by the time of the diagnosis.

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