%0 Generic %A Carmo, André Boziki Xavier do %A Sartoretto, Suelen Cristina %A Alves, Adriana Terezinha Neves Novellino %A Mauro Granjeiro, José %A Miguel, Fúlvio Borges %A Calasans-Maia, Jose %A Calasans-Maia, Monica Diuana %D 2018 %T Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite %U https://scielo.figshare.com/articles/dataset/Alveolar_bone_repair_with_strontium-_containing_nanostructured_carbonated_hydroxyapatite/5816103 %R 10.6084/m9.figshare.5816103.v1 %2 https://ndownloader.figshare.com/files/10284588 %2 https://ndownloader.figshare.com/files/10284591 %2 https://ndownloader.figshare.com/files/10284612 %2 https://ndownloader.figshare.com/files/10284618 %2 https://ndownloader.figshare.com/files/10284621 %2 https://ndownloader.figshare.com/files/10284630 %2 https://ndownloader.figshare.com/files/10284639 %K Hydroxyapatite %K Bone repair %K Rats %K Strontium %K Histomorphometric evaluation %X

ABSTRACT Objective: This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Methods: Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance. Results: The histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups. Conclusion: The CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes.

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