10.6084/m9.figshare.5809458.v1
Keng Hong Tee
Keng Hong
Tee
Gwendoline Cheng Lian Ee
Gwendoline
Cheng Lian Ee
Intan Safinar Ismail
Intan Safinar
Ismail
Thiruventhan Karunakaran
Thiruventhan
Karunakaran
Soek Sin Teh
Soek
Sin Teh
Vivien Yi Mian Jong
Vivien
Yi Mian Jong
Siti Mariam Mohd Nor
Siti Mariam Mohd
Nor
A new coumarin from stem bark of <i>Calophyllum wallichianum</i>
Taylor & Francis Group
2018
Calophyllum wallichianum
coumarin
anti-bacterial
2018-01-22 12:48:40
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/A_new_coumarin_from_stem_bark_of_i_Calophyllum_wallichianum_i_/5809458
<p>A phytochemical study carried out on the plant, <i>Calophyllum wallichianum</i> has led to the isolation of a new coumarin, wallimarin T (<b>1</b>) and a known coumarin, calanolide E (<b>2</b>) along with two common triterpenes, friedelin (<b>3</b>) and stigmasterol (<b>4</b>). The structures of these compounds were elucidated with the aid of spectroscopic analyses such as FT-IR, GC-MS, and NMR. MIC assay against the <i>Bacillus</i> bacteria were conducted on the extracts and this gave MIC values ranging from 0.313 to 1.25 mg/mL. Compound <b>2</b> was weakly inhibitory towards the <i>Bacilli</i> strains with MIC values ranging from 0.25–0.50 mg/mL. Wallimarin T <b>(1)</b> was not active towards all four bacteria. Overall, the extracts exhibited weak bactericidal properties whereas compound <b>2</b> was not bactericidal on the tested bacteria. The hexane and chloroform extracts of the plant were found to be inhibitors to the growth of <i>Bacillus megaterium</i>, <i>Bacillus cereus</i>, <i>Bacillus pumilus</i> and <i>Bacillus subtilis</i>.</p>