10.4225/03/5a69322db6468 SHAUNA LOUISE FRENCH SHAUNA LOUISE FRENCH Defining the role of protease-activated receptor 4 during thrombosis Monash University 2018 platelets thrombosis protease-activated receptor Cardiorespiratory Medicine and Haematology not elsewhere classified 2018-01-25 01:26:04 Thesis https://bridges.monash.edu/articles/thesis/Defining_the_role_of_protease-activated_receptor_4_during_thrombosis/5808813 Blood clots cause most heart attacks and strokes. Drugs such as aspirin are used to prevent heart attack and stroke but are frequently ineffective. This thesis identifies a new approach to stop blood clot formation and then develops and tests a candidate therapy that targets this new approach and that may improve heart attack and stroke prevention.