10.1371/journal.ppat.1006834.g007
Chunhong Yin
Chunhong
Yin
Niluka Goonawardane
Niluka
Goonawardane
Hazel Stewart
Hazel
Stewart
Mark Harris
Mark
Harris
V67A and P145A disrupted the co-localization between NS5A and Core or LDs.
Public Library of Science
2018
JFH -1-derived sub-genomic replicon
genome replication
HCV
lipid droplets
NS 5A domain
UTR
P 35A V 67A
virus genome replication
virus assembly
hepatitis C virus NS 5A protein
hepatitis C virus
V 67A
NS 5A
RNA
density gradient fractionation
NS 5A protein
P 145A
lipid droplet morphology
III
resolution confocal microscopy
II
2018-01-19 19:05:42
Figure
https://plos.figshare.com/articles/figure/V67A_and_P145A_disrupted_the_co-localization_between_NS5A_and_Core_or_LDs_/5806893
<p><b>A</b> Quantification of the percentages of NS5A colocalized with LD (white blocks), or LD colocalised with NS5A (red blocks). <b>B</b> Quantification of the percentages of NS5A colocalized with Core (white blocks), or Core colocalised with NS5A (green blocks). <b>C</b> Quantification of the percentages of Core colocalized with LD (green blocks), or LD colocalised with Core (red blocks). <b>D</b> Spatial data for the distance of LDs from the nuclear envelope were determined from 10 cells for each construct using Fiji. **** indicates significant difference (P<0.0001) from the results for WT.</p>