10.6084/m9.figshare.5793693.v1
Inoue T.
Inoue
T.
Ogura K.
Ogura
K.
Takahashi K.
Takahashi
K.
Nishino M.
Nishino
M.
Asaumi T.
Asaumi
T.
Yanagida N.
Yanagida
N.
Sato S.
Sato
S.
Ebisawa M.
Ebisawa
M.
Supplementary Material for: Risk Factors and Clinical Features in Cashew Nut Oral Food Challenges
Karger Publishers
2018
Allergy
Cashew nut
Risk factors
Allergic reaction
Oral food challenge
2018-01-17 09:06:14
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Risk_Factors_and_Clinical_Features_in_Cashew_Nut_Oral_Food_Challenges/5793693
<p><b><i>Background:</i></b> Cashew nuts (CN) are capable of causing
severe allergic reactions. However, little has been reported about the
details of CN oral food challenges (OFC). <b><i>Methods:</i></b>
CN-specific IgE (sIgE) levels were measured for 1 year in 66 patients
who underwent an OFC with >3 g CN for diagnosis or confirmation of
tolerance acquisition between June 2006 and August 2014. We
retrospectively analyzed the OFC and patient background. <b><i>Results:</i></b>
The median (IQR) age of the 66 patients (48 boys/men and 18
girls/women) was 7.0 years (5.7-8.8). Twelve patients (18.2%) had a
positive OFC result; 6 of 8 (75%) patients with a history of an
immediate reaction to CN failed the OFC. Anaphylaxis was experienced by 5
of these 12 (42%) patients. A history of an immediate reaction to CN
and the CN sIgE levels were significantly different for patients with a
positive or negative OFC result (<i>p</i> < 0.01). Among patients
without a previous immediate reaction to CN, the 95% positive predictive
value (PPV) for the CN sIgE level for a positive OFC result was 66.1 kU<sub>A</sub>/L. <b><i>Conclusions:</i></b>
A history of an immediate reaction to CN and high CN sIgE were risk
factors for a positive OFC result. The number of positive OFC results
was relatively low, but there was a high probability of anaphylaxis. We
should consider the indication of OFC carefully for patients with a
history of immediate reactions to CN and avoid OFC for patients without
such a history whose CN sIgE values are >66.1 kU<sub>A</sub>/L (95% PPV).</p>