%0 Figure %A Fernandez-Arias, Cristina %A Arias, Clemente F. %A Zhang, Min %A A. Herrero, Miguel %A Acosta, Francisco J. %A Tsuji, Moriya %D 2018 %T Numerical simulations of the model of homologous PB regimes with different parameters values. %U https://plos.figshare.com/articles/figure/Numerical_simulations_of_the_model_of_homologous_PB_regimes_with_different_parameters_values_/5784669 %R 10.1371/journal.pone.0190940.g003 %2 https://ndownloader.figshare.com/files/10951586 %K vaccine doses %K pre-erythrocytic stages %K clonal contraction %K T cell memory production %K sporozoite prime-boost vaccines Vaccination %K T cell response %K T cell dynamics %K Experimental data %K timing %K prime-boost vaccines %K Empirical evidence %K radiation-attenuated sporozoites %K model %K inoculation %X

A). Behavior of effector T cells after prime according to Eq (1). PB protocols are defined by choosing nine boost timings equally distributed between the initiation of the T cell response and the end of clonal contraction. B) Memory T cells formed for PB protocols that differ in prime dose and boost time, using a high total antigen dose. C) As B with lower antigen load. Results are normalized relative to the maximum in each figure. Black planes show the minimum value of memory formation for comparison. D,E) Same as B and C for a different choice of parameter values. The values of the parameters used in these simulations are the following (in suitable units): (B) A0 = 20000, λA = 450, c = 40, k = 250, λH = 10, φ = 107, μ = 1, α = 15, β = 0.04 and Ea(0) = Ma(0) = 10. (C) Same as in B, with A0 = 200. (D) A0 = 10000, λP = 250, c = 50, k = 120, λH = 10, φ = 107, μ = 1, A0 = 107, μ = 1, α = 2, β = 0.2 and Ea(0) = Ma(0) = 10. (E) Same as in C, with A0 = 1000.

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