Supplementary Material for: Low-Dose Oral Immunotherapy Using Low-Egg-Allergen Cookies for Severe Egg-Allergic Children Reduces Allergy Severity and Affects Allergen-Specific Antibodies in Serum
Maeta A.
Matsushima M.
Muraki N.
Asano M.
Takaoka Y.
Kameda M.
Takahashi K.
10.6084/m9.figshare.5782938.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Low-Dose_Oral_Immunotherapy_Using_Low-Egg-Allergen_Cookies_for_Severe_Egg-Allergic_Children_Reduces_Allergy_Severity_and_Affects_Allergen-Specific_Antibodies_in_Serum/5782938
<p><b><i>Background:</i></b> We evaluated the safety and efficacy of
low-egg-allergen cookies (LAC) as low-dose oral immunotherapy (OIT) in
children with severe egg allergy. We also examined the relationship
between mild desensitization by low-dose OIT and serum biomarkers of
allergy. <b><i>Methods:</i></b> We enrolled 13 children with egg allergy
who could not receive OIT with hard-boiled egg white (EW). For 11
participants, OIT was carried out using LAC for 3-4 months. Open food
challenges with hard-boiled EW and blood samplings were performed before
and after OIT. Participants were divided into 2 groups: high effect
(H-E) and no/low effect (N/L-E). Serum levels of total IgE and egg
yolk-, EW-, and ovomucoid (OM)-specific IgE, ovalbumin (OVA)- and
OM-specific IgG<sub>4</sub>, IgA<sub>1</sub>, and IgA<sub>2</sub>, and the percentage of CD 203c<sup>+</sup> were measured. <b><i>Results:</i></b>
Allergic severity was reduced in 7 patients, who were assigned to the
H-E group. Moreover, no study participants were taken off the intake of
LAC during OIT. In the H-E group, OVA-specific IgA<sub>2</sub> levels after OIT were significantly higher than before OIT. The ratios of OM-specific IgG<sub>4</sub>/OM-specific IgE and OM-specific IgA<sub>2</sub>/OM-specific IgE in the H-E group after OIT were significantly higher than before OIT. <b><i>Conclusion:</i></b> Our findings suggest that low-dose OIT using LAC is an effective and safe treatment for patients with severe egg allergy.</p>
2018-01-12 09:47:25
Oral administration
Low-allergen cookies
Egg allergy
Allergen-specific immunotherapy