A systematic review of Hepatitis B virus (HBV) drug and vaccine escape mutations in Africa
Jolynne Mokaya
Charlie Hadley
Philippa Matthews
10.6084/m9.figshare.5774091.v2
https://figshare.com/articles/dataset/A_systematic_review_of_Hepatitis_B_virus_HBV_drug_and_vaccine_escape_mutations_in_Africa/5774091
<p>We have undertaken a systematic review of Hepatitis B virus (HBV) drug resistance associated mutations (RAMs) and vaccine escape mutations (VEMs) in Africa to quantify the prevalence, co-occurrence and geographic distribution of known mutations. </p><p>Below are details of the files shared here:</p><p>S1 Fig: Flow diagram illustrating identification and inclusion of studies for a systematic review of drug and vaccine resistance mutations in Africa, based on PRISMA criteria;</p><p>S2 Fig: HBV drug RAMs grouped according to genotype;</p><p>S3 Fig: Distribution of HBV genotypes and prevalence of HBV RAMs in Pol/RT proteins in geno-A and geno-non-A samples;</p><p>S1 Table: Details of search strategy used to identify studies on HBV RAMs and VEMs conducted in Africa;</p><p>S2 Table: Full details of 37 studies identified by a systematic literature search of HBV RAMs and VEMs from African cohorts published between 2007 and 2017 (inclusive);</p><p>S3 Table: HBV Pol/RT mutations among treatment-naïve HBV infected patients in Africa from 12 studies published between 2007 and 2017 (inclusive);</p><p>S4 Table: HBV Pol/RT mutations among treatment-experienced HBV infected patients in Africa, from 25 studies published between 2009 and 2017 (inclusive).</p>
2018-02-01 12:27:37
Hepatitis B Drugs
Hepatitis B Virus
Africa populations
HIV
drug resistance
Vaccine resistance
Antiviral therapy
lamivudine-resistant HBV infection
Tenofovir
Medical Virology