TY - DATA T1 - Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review PY - 2018/01/10 AU - Carlos Henrique Pires Ratto Tavares Bello AU - João Sequeira Duarte AU - Carlos Vasconcelos UR - https://scielo.figshare.com/articles/dataset/Diabetes_mellitus_and_hyperkalemic_renal_tubular_acidosis_case_reports_and_literature_review/5772639 DO - 10.6084/m9.figshare.5772639.v1 L4 - https://ndownloader.figshare.com/files/10181016 L4 - https://ndownloader.figshare.com/files/10181022 L4 - https://ndownloader.figshare.com/files/10181037 KW - acidosis KW - acidosis, renal tubular KW - diabetes mellitus KW - hyperkalemia KW - hypoaldosteronism N2 - ABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited. ER -