10.6084/m9.figshare.5772348.v1
Henrique Cotchi Simbo Muela
Henrique Cotchi Simbo
Muela
Valeria A. Costa-Hong
Valeria A.
Costa-Hong
Monica Sanches Yassuda
Monica Sanches
Yassuda
Michel Ferreira Machado
Michel Ferreira
Machado
Ricardo de Carvalho Nogueira
Ricardo de Carvalho
Nogueira
Natalia C. Moraes
Natalia C.
Moraes
Claudia Maia Memória
Claudia Maia
Memória
Thiago A. Macedo
Thiago A.
Macedo
Edson Bor-Seng-Shu
Edson
Bor-Seng-Shu
Ayrton Roberto Massaro
Ayrton Roberto
Massaro
Ricardo Nitrini
Ricardo
Nitrini
Luiz A. Bortolotto
Luiz A.
Bortolotto
Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
SciELO journals
2018
hypertension
vascular changes
arterial stiffness
cerebral blood flow
cognitive performance
2018-01-10 05:55:09
Dataset
https://scielo.figshare.com/articles/dataset/Impact_of_hypertension_severity_on_arterial_stiffness_cerebral_vasoreactivity_and_cognitive_performance/5772348
<div><p>ABSTRACT. Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural and functional changes of the arterial wall. Objective: To evaluate whether arterial stiffness (AS) is related to cerebral blood flow changes and its association with cognitive function in patients with hypertension. Methods: 211 patients (69 normotensive and 142 hypertensive) were included. Patients with hypertension were divided into 2 stages: HTN stage-1 and HTN stage-2. The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA) and a battery of neuropsychological (NPE) tests were used to determine cognitive function. Pulse wave velocity was measured using the Complior®. Carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. Middle cerebral artery flow velocity was measured by transcranial Doppler ultrasonography. Results: Both arterial stiffness parameters and cerebral vasoreactivity worsened in line with HTN severity. There was a negative correlation between breath holding index (BHI) and arterial stiffness parameters. Cognitive performance worsened in line with HTN severity, with statistical difference occurring mainly between the HTN-2 and normotension groups on both the MMSE and MoCA. The same tendency was observed on the NPE tests. Conclusion: Hypertension severity was associated with higher AS, worse BHI, and lower cognitive performance.</p></div>