TY - DATA T1 - Distribution of TMEM173/STING HAQ and R232H in patients and healthy controls from Netherlands cohort. PY - 2018/01/03 AU - Juan S. Ruiz-Moreno AU - Lutz Hamann AU - Javeed A. Shah AU - Annelies Verbon AU - Frank P. Mockenhaupt AU - Monika Puzianowska-Kuznicka AU - Jan Naujoks AU - Leif E. Sander AU - Martin Witzenrath AU - John C. Cambier AU - Norbert Suttorp AU - Ralf R. Schumann AU - Lei Jin AU - Thomas R. Hawn AU - Bastian Opitz UR - https://plos.figshare.com/articles/dataset/Distribution_of_i_TMEM173_STING_i_HAQ_and_R232H_in_patients_and_healthy_controls_from_Netherlands_cohort_/5755278 DO - 10.1371/journal.ppat.1006829.t002 L4 - https://ndownloader.figshare.com/files/10136898 KW - R 232H attenuated cytokine production KW - susceptibility KW - STING-deficient murine macrophages KW - R 232H alleles KW - cyclic GMP-AMP synthase KW - STING-deficient animals KW - cyclic dinucleotides KW - TMEM KW - IFN KW - protozoal infections KW - Recent studies KW - HAQ STING variant impairs cGAS-dependent KW - cGAS-STING cascade KW - Legionnaire KW - haplotype frequency KW - DNA KW - Trial registration ClinicalTrials.gov DRKS 00005274 KW - CDN KW - mouse model KW - wild-type mice KW - Legionella pneumophila KW - response KW - pro-inflammatory cytokines N2 - Distribution of TMEM173/STING HAQ and R232H in patients and healthy controls from Netherlands cohort. ER -