Distribution of <i>TMEM173/STING</i> HAQ and R232H in patients and healthy controls from Netherlands cohort.
Juan S. Ruiz-Moreno
Lutz Hamann
Javeed A. Shah
Annelies Verbon
Frank P. Mockenhaupt
Monika Puzianowska-Kuznicka
Jan Naujoks
Leif E. Sander
Martin Witzenrath
John C. Cambier
Norbert Suttorp
Ralf R. Schumann
Lei Jin
Thomas R. Hawn
Bastian Opitz
10.1371/journal.ppat.1006829.t002
https://plos.figshare.com/articles/dataset/Distribution_of_i_TMEM173_STING_i_HAQ_and_R232H_in_patients_and_healthy_controls_from_Netherlands_cohort_/5755278
<p>Distribution of <i>TMEM173/STING</i> HAQ and R232H in patients and healthy controls from Netherlands cohort.</p>
2018-01-03 18:40:52
R 232H attenuated cytokine production
susceptibility
STING-deficient murine macrophages
R 232H alleles
cyclic GMP-AMP synthase
STING-deficient animals
cyclic dinucleotides
TMEM
IFN
protozoal infections
Recent studies
HAQ STING variant impairs cGAS-dependent
cGAS-STING cascade
Legionnaire
haplotype frequency
DNA
Trial registration ClinicalTrials.gov DRKS 00005274
CDN
mouse model
wild-type mice
Legionella pneumophila
response
pro-inflammatory cytokines