Distribution of <i>TMEM173/STING</i> HAQ and R232H in patients and healthy controls from Netherlands cohort. Juan S. Ruiz-Moreno Lutz Hamann Javeed A. Shah Annelies Verbon Frank P. Mockenhaupt Monika Puzianowska-Kuznicka Jan Naujoks Leif E. Sander Martin Witzenrath John C. Cambier Norbert Suttorp Ralf R. Schumann Lei Jin Thomas R. Hawn Bastian Opitz 10.1371/journal.ppat.1006829.t002 https://plos.figshare.com/articles/dataset/Distribution_of_i_TMEM173_STING_i_HAQ_and_R232H_in_patients_and_healthy_controls_from_Netherlands_cohort_/5755278 <p>Distribution of <i>TMEM173/STING</i> HAQ and R232H in patients and healthy controls from Netherlands cohort.</p> 2018-01-03 18:40:52 R 232H attenuated cytokine production susceptibility STING-deficient murine macrophages R 232H alleles cyclic GMP-AMP synthase STING-deficient animals cyclic dinucleotides TMEM IFN protozoal infections Recent studies HAQ STING variant impairs cGAS-dependent cGAS-STING cascade Legionnaire haplotype frequency DNA Trial registration ClinicalTrials.gov DRKS 00005274 CDN mouse model wild-type mice Legionella pneumophila response pro-inflammatory cytokines