Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase - Fig 6 Joanna Gerszon Eligiusz Serafin Adam Buczkowski Sylwia Michlewska Jakub Antoni Bielnicki Aleksandra Rodacka 10.1371/journal.pone.0190656.g006 https://plos.figshare.com/articles/figure/Functional_consequences_of_piceatannol_binding_to_glyceraldehyde-3-phosphate_dehydrogenase_-_Fig_6/5755170 <p><b>(A)</b> The largest accessible region in GAPDH tetramer for piceatannol binding is located inside the molecule, where the subunits come into contact. <b>(B)</b> Interactions of piceatannol inside the molecule with amino acid residues from subunit O and Q.</p> 2018-01-03 18:39:11 oxidative modifications nucleophilic cysteine residue glyceraldehyde -3-phosphate dehydrogenase Glyceraldehyde -3-phosphate dehydrogenase GAPDH aggregation 11 ligand binding positions ITC GAPDH piceatannol blocks cysteine residue piceatannol decreases GAPDH activity reactive cysteine residue