Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase - Fig 6
Joanna Gerszon
Eligiusz Serafin
Adam Buczkowski
Sylwia Michlewska
Jakub Antoni Bielnicki
Aleksandra Rodacka
10.1371/journal.pone.0190656.g006
https://plos.figshare.com/articles/figure/Functional_consequences_of_piceatannol_binding_to_glyceraldehyde-3-phosphate_dehydrogenase_-_Fig_6/5755170
<p><b>(A)</b> The largest accessible region in GAPDH tetramer for piceatannol binding is located inside the molecule, where the subunits come into contact. <b>(B)</b> Interactions of piceatannol inside the molecule with amino acid residues from subunit O and Q.</p>
2018-01-03 18:39:11
oxidative modifications
nucleophilic cysteine residue
glyceraldehyde -3-phosphate dehydrogenase Glyceraldehyde -3-phosphate dehydrogenase
GAPDH aggregation
11 ligand binding positions
ITC
GAPDH piceatannol blocks cysteine residue
piceatannol decreases GAPDH activity
reactive cysteine residue