%0 Figure %A Grundy, Martin %A Seedhouse, Claire %A Jones, Thomas %A Elmi, Liban %A Hall, Michael %A Graham, Adam %A Russell, Nigel %A Pallis, Monica %D 2018 %T Dynamic BH3 profiling assay: delta priming to PUMA-BH3. %U https://plos.figshare.com/articles/figure/Dynamic_BH3_profiling_assay_delta_priming_to_PUMA-BH3_/5755158 %R 10.1371/journal.pone.0190682.g001 %2 https://ndownloader.figshare.com/files/10138812 %K drugs sensitising %K pro-apoptotic anti-leukaemic drug combinations %K BH 3-only apoptosis agonists BAD %K MCL -1-targeting MS 1-BH peptide %K etoposide %K BAD-BH 3-mediated mitochondrial %K NOXA target BCL -2 %K anti-leukaemic drugs sensitising %K AC 220 %K BCL -2-targeting BAD-BH 3 peptide %K 4 hours %K membrane permeabilisation %K agents sensitised cells %K BH 3 %K BCL -2 %K DNA %K inhibitors pladienolide B %K FLT 3 inhibitor AC 220 %K cytochrome C release %K pladienolide B %K compounds ABT -199 %K BCL -2 inhibitors ABT -199 %K BET domain inhibitor JQ 1 %K downregulate BCL -2 %K BCL -2 antagonism %X

The increase in cells primed to undergo mitochondrial outer membrane depolarisation (Δ priming) is measured by Cytochrome C release after 4 hour drug treatment. PUMA-BH3 was used at 3 μM. Values are corrected for Cytochrome C release with peptide only as described in the methods. (Mean+/- SD for n = 3).

%I PLOS ONE