cSBL showed <i>in vivo</i> cytotoxicity without inducing loss of body weight.
Takeo Tatsuta
Toshiyuki Satoh
Shigeki Sugawara
Akiyoshi Hara
Masahiro Hosono
10.1371/journal.pone.0190653.g004
https://figshare.com/articles/cSBL_showed_i_in_vivo_i_cytotoxicity_without_inducing_loss_of_body_weight_/5755101
<p>Mice were randomly divided into 3 groups with 10 mice in each group. Groups 1, 2, and 3 were injected PBS, pemetrexed (100 mg/kg, intraperitoneally), and cSBL (2.5 mg/kg, intratumorally), respectively. Body weights and tumor sizes were measured twice per week. Tumor volumes were calculated as follows: 0.4×A×B<sup>2</sup>, where A and B represent the long and short diameters (in mm) of the tumor, respectively. Relative body weight (A, B) and relative tumor volume (C, D) are plotted as the mean of each group ± SD at each timepoint. The statistical significance of these experiments compared with PBS (*) or pemetrexed (<sup>†</sup>) is shown as follows: *P<0.05, **P<0.01, ***P<0.001, <sup>†</sup>P<0.01, <sup>†††</sup>P<0.001.</p>
2018-01-03 18:38:56
cSBL
vivo Malignant mesothelioma
Sialic acid-binding lectin
mesothelioma cell lines
cell lines
exhibits antitumor activity
MSTO
pemetrexed
RNA
Xenograft-competent H 2452
mesothelioma cell growth
Caspase cascade analysis
Rana catesbeiana oocytes
dose reduction index values