NGUYEN, MY-NHAN Cardiac Remodelling and Fibrosis in Cardiomyopathy: Role of Galectin-3 This thesis provides a comprehensive investigation on the contribution of heart scarring, known as cardiac fibrosis, to remodelling and impaired function of the heart. It highlights a relationship between the presence of cardiac fibrosis and severity of irregular heartbeats, and demonstrated the complex role of a molecule called ‘galectin-3’ in the pathogenesis of fibrosis and remodelling in cardiomyopathy. The thesis provides new mechanisms for elevation of galectin-3 blood levels that is invaluable for clinical use of galectin-3 as a predictor of heart disease. Collectively, these works have advanced our understanding of cardiac fibrosis and galectin-3 in heart disease. galectin-3;cardiac fibrosis;arrhythmias;beta-2 adrenergic receptor;mammalian sterile 20-like kinase 1;biomarker;transgenic mouse models;cardiac remodelling;cardiomyopathy;heart;Physiology;Cardiology (incl. Cardiovascular Diseases) 2018-01-05
    https://bridges.monash.edu/articles/thesis/Cardiac_Remodelling_and_Fibrosis_in_Cardiomyopathy_Role_of_Galectin-3/5752398
10.4225/03/5a4ec3da73674