Regioselective Halogenation
of Arenes and Heterocycles
in Hexafluoroisopropanol
Ren-Jin Tang
Thierry Milcent
Benoit Crousse
10.1021/acs.joc.7b02920.s001
https://acs.figshare.com/articles/journal_contribution/Regioselective_Halogenation_of_Arenes_and_Heterocycles_in_Hexafluoroisopropanol/5747193
Regioselective halogenation
of arenes and heterocycles with <i>N</i>-halosuccinimides
in fluorinated alcohols is disclosed.
Under mild condition reactions, a wide diversity of halogenated arenes
are obtained in good yields with high regioselectivity. Additionally,
the versatility of the method is demonstrated by the development of
one-pot sequential halogenation and halogenation-Suzuki cross-coupling
reactions.
2017-12-19 00:00:00
one-pot sequential halogenation
diversity
condition reactions
regioselectivity
Heterocycle
Hexafluoroisopropanol Regioselective halogenation
halogenation-Suzuki cross-coupling reactions
halosuccinimide
Regioselective Halogenation
method
Arene
heterocycle
versatility
arene
yield