10.6084/m9.figshare.5739567.v1
Hamdy K. Assaf
Hamdy K.
Assaf
Alaa M. Nafady
Alaa M.
Nafady
Ahmed E. Allam
Ahmed E.
Allam
Ashraf N. E. Hamed
Ashraf N. E.
Hamed
Mohamed S. Kamel
Mohamed S.
Kamel
Kuniyoshi Shimizu
Kuniyoshi
Shimizu
Forsskamide, a new ceramide from aerial parts of <i>Forsskaolea tenacissima</i> Linn.
Taylor & Francis Group
2017
Forsskaolea tenacissima
Urticaceae
Forsskamide
ceramide and cytotoxicity
2017-12-28 05:26:25
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Forsskamide_a_new_ceramide_from_aerial_parts_of_i_Forsskaolea_tenacissima_i_Linn_/5739567
<p>Although the various folk medicine uses and the biological activity of <i>Forsskaolea tenacissima</i> L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of <i>F. tenacissima</i> L. (Urticaceae). The chemical structure was established by different spectroscopic methods (<sup>1</sup>H, <sup>13</sup>C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC<sub>50</sub> 33.25 μM in comparison with 5-fluorouracil IC<sub>50</sub> 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).</p>