Yanamala, Naveena Kisin, Elena R. W. Gutkin, Dmitriy Shurin, Michael R. Harper, Martin Shvedova, Anna A. Characterization of pulmonary responses in mice to asbestos/asbestiform fibers using gene expression profiles <p>Humans exposed to asbestos and/or asbestiform fibers are at high risk of developing many lung diseases including asbestosis, lung cancer, and malignant mesothelioma. However, the disease-causing potential and specific metabolic mechanisms and pathways associated with various asbestos/asbestiform fiber exposures triggering different carcinogenic and non-carcinogenic outcomes are still largely unknown. The aim of this this study was to investigate gene expression profiles and inflammatory responses to different asbestos/asbestiform fibers at the acute/sub-acute phase that may be related to delayed pathological outcomes observed at later time points. Mice were exposed to asbestos (crocidolite, tremolite asbestos), asbestiform fibers (erionite), and a low pathogenicity mineral fiber (wollastonite) using oropharyngeal aspiration. Similarities in inflammatory and tissue damage responses, albeit with quantitative differences, were observed at day 1 and 7 post treatment. Exposure to different fibers induced significant changes in regulation and release of a number of inflammatory cytokines/chemokines. Comparative analysis of changes in gene regulation in the lung on day 7 post exposure were interpretable in the context of differential biological responses that were consistent with histopathological findings at days 7 and 56 post treatment. Our results noted differences in the magnitudes of pulmonary responses and gene regulation consistent with pathological alterations induced by exposures to four asbestos/asbestiform fibers examined. Further comparative mechanistic studies linking early responses with the long-term endpoints may be instrumental to understanding triggering mechanisms underlying pulmonary carcinogenesis, that is lung cancer versus mesothelioma.</p> asbestos;tissue damage responses;56 post treatment;gene expression profiles;gene expression profiles Humans;7 post treatment;gene regulation;day 7 post exposure;pathogenicity mineral fiber;lung cancer 2017-12-27
    https://tandf.figshare.com/articles/dataset/Characterization_of_pulmonary_responses_in_mice_to_asbestos_asbestiform_fibers_using_gene_expression_profiles/5734728
10.6084/m9.figshare.5734728