NEW SEMISYNTHETIC DERIVATIVES OF A BENZYLISOTHIOCYANATE ISOLATED FROM Moringa oleifera AND EVALUATION OF THEIR CYTOTOXIC ACTIVITY
Diana Kelly C. de Almeida
Marcos R. da Silva
Maria Conceição F. de Oliveira
Jair Mafezoli
Marcos C. de Mattos
Andréa F. Moura
Manoel O. Moraes Filho
Francisco G. Barbosa
10.6084/m9.figshare.5734491.v1
https://scielo.figshare.com/articles/dataset/NEW_SEMISYNTHETIC_DERIVATIVES_OF_A_BENZYLISOTHIOCYANATE_ISOLATED_FROM_Moringa_oleifera_AND_EVALUATION_OF_THEIR_CYTOTOXIC_ACTIVITY/5734491
<div><p>From the natural product 4-(4'-O-acetyl-α-L-rhamnosyloxy)benzylisothiocyanate (1), isolated from the flowers of Moringa oleifera Lam (Moringaceae), four new semisynthetic derivatives, N-[4-(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]-2-(pyridinil-4-carbonil)hydrazine-1-carbothioamide (3), 4-(4'-O-acetyl-2',3'-dimesyloxy-α-L-rhamnosyloxy)benzylisothiocyanate (4), N-[(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]hydrazinecarbothioamide (5), 4-[4'-O-acetyl-2',3'-O-bis(decanoiloxy)-α-L-rhamnosyloxy]benzylisothiocianate (6), and the known compound 4-(2',3',4'-O-triacetyl-α-L-rhamnosyloxy)benzylisothiocyanate (2), were obtained. All compounds were tested for their cytotoxicity against the tumor cell lines SF-295, HL-60, HCT-116 e PC-3. The natural product 1 and the semisynthetic derivatives 2 and 4 were the most active compounds (IC50 from16.0 to 3.7 µmol L-1) against all tumor cell lines.</p></div>
2017-12-27 02:44:34
benzylisothiocyanate
Moringa oleifera
cytotoxic activity
semisynthetic derivatives