NEW SEMISYNTHETIC DERIVATIVES OF A BENZYLISOTHIOCYANATE ISOLATED FROM Moringa oleifera AND EVALUATION OF THEIR CYTOTOXIC ACTIVITY Diana Kelly C. de Almeida Marcos R. da Silva Maria Conceição F. de Oliveira Jair Mafezoli Marcos C. de Mattos Andréa F. Moura Manoel O. Moraes Filho Francisco G. Barbosa 10.6084/m9.figshare.5734491.v1 https://scielo.figshare.com/articles/dataset/NEW_SEMISYNTHETIC_DERIVATIVES_OF_A_BENZYLISOTHIOCYANATE_ISOLATED_FROM_Moringa_oleifera_AND_EVALUATION_OF_THEIR_CYTOTOXIC_ACTIVITY/5734491 <div><p>From the natural product 4-(4'-O-acetyl-α-L-rhamnosyloxy)benzylisothiocyanate (1), isolated from the flowers of Moringa oleifera Lam (Moringaceae), four new semisynthetic derivatives, N-[4-(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]-2-(pyridinil-4-carbonil)hydrazine-1-carbothioamide (3), 4-(4'-O-acetyl-2',3'-dimesyloxy-α-L-rhamnosyloxy)benzylisothiocyanate (4), N-[(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]hydrazinecarbothioamide (5), 4-[4'-O-acetyl-2',3'-O-bis(decanoiloxy)-α-L-rhamnosyloxy]benzylisothiocianate (6), and the known compound 4-(2',3',4'-O-triacetyl-α-L-rhamnosyloxy)benzylisothiocyanate (2), were obtained. All compounds were tested for their cytotoxicity against the tumor cell lines SF-295, HL-60, HCT-116 e PC-3. The natural product 1 and the semisynthetic derivatives 2 and 4 were the most active compounds (IC50 from16.0 to 3.7 µmol L-1) against all tumor cell lines.</p></div> 2017-12-27 02:44:34 benzylisothiocyanate Moringa oleifera cytotoxic activity semisynthetic derivatives