%0 Journal Article %A Kreisel, Stefan %A Blahak, Christian %A Bäzner, HansjÜrg %A Hennerici, Michael %D 2017 %T Additional file 1: of Does being physically active prevent future disability in older people? Attenuated effects when taking time-dependent confounders into account %U https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Does_being_physically_active_prevent_future_disability_in_older_people_Attenuated_effects_when_taking_time-dependent_confounders_into_account/5728710 %R 10.6084/m9.figshare.5728710.v1 %2 https://ndownloader.figshare.com/files/10075314 %K Physical activity %K Marginal structural models %K Causal inference %K Age-related white matter lesions %K Disability %K Longitudinal observational studies %X Supporting information. The Supporting information provides a non-technical introduction on how marginal structural models can be estimated generically. We provide a practical demonstration of how to implement this type of modeling using standard statistical software, discussing benefits and caveats. We include an additional figure that highlights the underpinnings of time-varying treatment, time-varying confounding and the inverse probability of treatment weight. The estimation steps presented in the main manuscript are cross-referenced in the Supporting information. (DOC 1488 kb) %I figshare