Thermodynamic and kinetic analysis of the reaction between biological catecholamines and chlorinated methylperoxy radicals Dušan S. Dimić Dejan A. Milenković Jasmina M. Dimitrić Marković Zoran S. Marković 10.6084/m9.figshare.5724502.v1 https://tandf.figshare.com/articles/journal_contribution/Thermodynamic_and_kinetic_analysis_of_the_reaction_between_biological_catecholamines_and_chlorinated_methylperoxy_radicals/5724502 <p>The antiradical potency of catecholamines (dopamine, epinephrine, norepinephrine, L-DOPA), metabolites of dopamine (homovanillic acid, 3-methoxytyramine and 3,4-dihydroxyphenylacetic acid) and catechol towards substituted methylperoxy radicals is investigated. The thermodynamic parameters, together with the kinetic approach, are used to determine the most probable mechanism of action. The natural bond orbital and quantum theory of atoms in molecules are utilised to explain the highest reactivity of trichloromethylperoxy radical. The preferred mechanism is dependent both on the thermodynamic and kinetic parameters . The number of chlorine atoms on radical, the presence of intra-molecular hydrogen bond and number of hydroxy groups attached to the aromatic ring significantly influence the mechanism. The results suggest that sequential proton loss electron transfer (SPLET) is the most probable for reaction with methylperoxy and hydrogen atom transfer (HAT) for reaction with trichloromethylperoxy radicals, with a gradual transition between SPLET and HAT for other two radicals. Due to the significant deprotonation of molecules containing the carboxyl group, the respective anions are also investigated. The HAT and SPLET mechanisms are highly competitive in reaction with MP radical, while the dominant mechanism towards chlorinated radicals is HAT. The reactions in methanol and benzene are also discussed.</p> 2017-12-20 18:39:10 Marcus’ theory free radicals HAT SPLET neurotransmitters