TY - DATA T1 - Porous Titanium Associated with CaP Coating: In Vivo and In Vitro Osteogenic Performance PY - 2017/12/20 AU - Luana Marotta Reis de Vasconcellos AU - Rodrigo Dias Nascimento AU - Carlos Alberto Alves Cairo AU - Daniel de Oliveira Leite AU - Evelyn Luzia de Souza Santos AU - Gabriela Esteves Campos AU - Renata Falchete do Prado AU - Maria Aparecida Neves Jardini AU - Luis Gustavo Oliveira de Vasconcellos AU - Yasmin Rodarte Carvalho UR - https://scielo.figshare.com/articles/dataset/Porous_Titanium_Associated_with_CaP_Coating_In_Vivo_and_In_Vitro_Osteogenic_Performance/5719330 DO - 10.6084/m9.figshare.5719330.v1 L4 - https://ndownloader.figshare.com/files/10044652 L4 - https://ndownloader.figshare.com/files/10044658 L4 - https://ndownloader.figshare.com/files/10044664 L4 - https://ndownloader.figshare.com/files/10044670 L4 - https://ndownloader.figshare.com/files/10044682 L4 - https://ndownloader.figshare.com/files/10044688 L4 - https://ndownloader.figshare.com/files/10044697 L4 - https://ndownloader.figshare.com/files/10044700 L4 - https://ndownloader.figshare.com/files/10044715 L4 - https://ndownloader.figshare.com/files/10044718 KW - bone in-growth KW - CaP coating KW - porous titanium KW - ALP KW - surface-cell adhesion N2 - This in vitro and in vivo study compared different topographies of Ti samples (dense, porosity of 30% and 40%) with or not CaP coating, prepared by powder metallurgy. Osteogenic cells from newborn rat calvaria were plated onto the samples and cell adhesion (24 hours), alkaline phosphatase activity (7 and 10 days) and mineralization nodules (14 days) were assessed. Sixteen rabbits were used for in vivo study. Each animal received three non-treated and three treated implants in the right or left tibia, respectively. Histometric evaluation of bone-implant contact (BIC) were assessed at 1, 2, 4 and 8 weeks. Metallographic analysis revealed porosities of 30% and 40%, with pore size ranging from 250 to 350 µm. Cell adhesion test and ALP revealed similar cell behavior, independently of topography and CaP coating (P > 0.05%). However, CaP coating combined with porosity of 40% influenced positively the mineralized matrix formation (P < 0.05%). CaP-coated implants showed higher BIC than non-CaP implants and BIC was different between the short (1 and 2 weeks) and long (4 and 8 weeks) healing periods (P < 0.05%). The results suggest that CaP coating combined with 40% porosity implants allowed greater osteogenesis in vitro and increased BIC in vivo. ER -