TY - DATA T1 - Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review PY - 2017/12/20 AU - Vanessa Ramos Pires Dinarte AU - Anemari Ramos Dinarte dos Santos AU - Luiza Ferreira de Araújo AU - Mariah Guieiro Alves dos Reis AU - Edwin Tamashiro AU - Fabiana Cardoso Pereira Valera AU - Wilson Araújo da Silva Júnior AU - Wilma Terezinha Anselmo-Lima UR - https://scielo.figshare.com/articles/dataset/Polymorphisms_in_chronic_rhinosinusitis_with_nasal_polyps_-_a_systematic_review/5719288 DO - 10.6084/m9.figshare.5719288.v1 L4 - https://ndownloader.figshare.com/files/35670151 L4 - https://ndownloader.figshare.com/files/35670154 KW - Polymorphism KW - Rhinosinusitis KW - Polyps N2 - Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. Conclusion: Genetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors. ER -