10.6084/m9.figshare.5695966.v1
José Roberto Fioretto
José Roberto
Fioretto
Susiane Oliveira Klefens
Susiane Oliveira
Klefens
Rafaelle Fernandes Pires
Rafaelle Fernandes
Pires
Cilmery Suemi Kurokawa
Cilmery Suemi
Kurokawa
Mario Ferreira Carpi
Mario Ferreira
Carpi
Rossano César Bonatto
Rossano César
Bonatto
Marcos Aurélio Moraes
Marcos Aurélio
Moraes
Carlos Fernando Ronchi
Carlos Fernando
Ronchi
Comparison between conventional protective mechanical ventilation and high-frequency oscillatory ventilation associated with the prone position
SciELO journals
2017
Respiration, artificial
Acute lung injury
High-frequency ventilation
Oxidative stress
Acute respiratory distress syndrome
Rabbits
2017-12-13 02:42:21
Dataset
https://scielo.figshare.com/articles/dataset/Comparison_between_conventional_protective_mechanical_ventilation_and_high-frequency_oscillatory_ventilation_associated_with_the_prone_position/5695966
<p></p><p>ABSTRACT Objective: To compare the effects of high-frequency oscillatory ventilation and conventional protective mechanical ventilation associated with the prone position on oxygenation, histology and pulmonary oxidative damage in an experimental model of acute lung injury. Methods: Forty-five rabbits with tracheostomy and vascular access were underwent mechanical ventilation. Acute lung injury was induced by tracheal infusion of warm saline. Three experimental groups were formed: healthy animals + conventional protective mechanical ventilation, supine position (Control Group; n = 15); animals with acute lung injury + conventional protective mechanical ventilation, prone position (CMVG; n = 15); and animals with acute lung injury + high-frequency oscillatory ventilation, prone position (HFOG; n = 15). Ten minutes after the beginning of the specific ventilation of each group, arterial gasometry was collected, with this timepoint being called time zero, after which the animal was placed in prone position and remained in this position for 4 hours. Oxidative stress was evaluated by the total antioxidant performance assay. Pulmonary tissue injury was determined by histopathological score. The level of significance was 5%. Results: Both groups with acute lung injury showed worsening of oxygenation after induction of injury compared with the Control Group. After 4 hours, there was a significant improvement in oxygenation in the HFOG group compared with CMVG. Analysis of total antioxidant performance in plasma showed greater protection in HFOG. HFOG had a lower histopathological lesion score in lung tissue than CMVG. Conclusion: High-frequency oscillatory ventilation, associated with prone position, improves oxygenation and attenuates oxidative damage and histopathological lung injury compared with conventional protective mechanical ventilation.</p><p></p>