TY - DATA T1 - Collagen sponge and rhBMP-2 improve socket healing in rats treated with zoledronic acid PY - 2017/12/13 AU - Ji-Su OH AU - Su-Gwan KIM UR - https://scielo.figshare.com/articles/dataset/Collagen_sponge_and_rhBMP-2_improve_socket_healing_in_rats_treated_with_zoledronic_acid/5695933 DO - 10.6084/m9.figshare.5695933.v1 L4 - https://ndownloader.figshare.com/files/9975793 L4 - https://ndownloader.figshare.com/files/9975802 L4 - https://ndownloader.figshare.com/files/9975808 L4 - https://ndownloader.figshare.com/files/9975817 KW - Bone and Bones KW - Bisphosphonate KW - Osteonecrosis KW - Tooth Extraction N2 - Abstract The aim of the present study was to evaluate the possible use of a commercial absorbed collagen sponge and bone morphogenetic protein (BMP) for the prevention of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in rats. Twenty rats received intraperitoneal injections of 0.1-mg/kg of zoledronic acid three times a week for eight weeks before the extraction of both maxillary first molars after eight weeks. A collagen sponge (experimental group 1) and a collagen sponge with recombinant human BMP-2 (experimental group 2) were applied to the right extraction sockets of ten rats each. The 20 left extraction sockets (control groups 1 and 2) were left unprotected. After eight weeks, all rats were euthanized. Macroscopic analysis, micro-computed tomography (CT) analysis, and histological analysis were performed. There was a significant difference in the bone density between the control and experimental groups on micro-CT analysis. Impaired healing of the extraction sockets, indicating BRONJ, was observed in 80% of control group 1, 90% of control group 2, 30% of experimental group 1, and 20% of experimental group 2. The collagen sponge with/without BMP used for protecting the extraction socket had the potential for a positive effect in reducing the incidence of bisphosphonate-related osteonecrosis of the jaw in rats. ER -