10.6084/m9.figshare.5695831.v1 Maurício Domingues Ferreira Maurício Domingues Ferreira Anna Cristina Collaniere Anna Cristina Collaniere Dalton Luís Bertolini Dalton Luís Bertolini Noac Chuffi Barros Noac Chuffi Barros Dewton de Moraes Vasconcelos Dewton de Moraes Vasconcelos Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency? SciELO journals 2017 Schistosomiasis Immunodeficiency Chronic dermatophytosis 2017-12-13 02:41:03 Dataset https://scielo.figshare.com/articles/dataset/Cellular_immunodeficiency_related_to_chronic_dermatophytosis_in_a_patient_with_Schistosoma_mansoni_infection_can_schistosomiasis_induce_immunodeficiency_/5695831 <div><p>Abstract: Here, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulation of a large amount of blood cells in the spleen could have played a crucial role in the development of lymphocytopenia in the present case. Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-γ, a cytokine fundamental to fungal resistance. This case shows the potential of hepatosplenic schistosomiasis to impair the immune response.</p></div>