10.6084/m9.figshare.5695831.v1
Maurício Domingues Ferreira
Maurício Domingues
Ferreira
Anna Cristina Collaniere
Anna Cristina
Collaniere
Dalton Luís Bertolini
Dalton Luís
Bertolini
Noac Chuffi Barros
Noac Chuffi
Barros
Dewton de Moraes Vasconcelos
Dewton de Moraes
Vasconcelos
Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency?
SciELO journals
2017
Schistosomiasis
Immunodeficiency
Chronic dermatophytosis
2017-12-13 02:41:03
Dataset
https://scielo.figshare.com/articles/dataset/Cellular_immunodeficiency_related_to_chronic_dermatophytosis_in_a_patient_with_Schistosoma_mansoni_infection_can_schistosomiasis_induce_immunodeficiency_/5695831
<div><p>Abstract: Here, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulation of a large amount of blood cells in the spleen could have played a crucial role in the development of lymphocytopenia in the present case. Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-γ, a cytokine fundamental to fungal resistance. This case shows the potential of hepatosplenic schistosomiasis to impair the immune response.</p></div>