10.6084/m9.figshare.5695729.v1 Thiago R. Padilha Amarante Thiago R. Padilha Amarante Sibele Y. M. Takeda Sibele Y. M. Takeda Hélio A. G. Teive Hélio A. G. Teive Marise Bueno Zonta Marise Bueno Zonta Impact of disease duration on functional status of patients with spinocerebellar ataxia type 2 SciELO journals 2017 spinocerebellar ataxias severity of illness index postural balance 2017-12-13 02:40:17 Dataset https://scielo.figshare.com/articles/dataset/Impact_of_disease_duration_on_functional_status_of_patients_with_spinocerebellar_ataxia_type_2/5695729 <div><p>ABSTRACT Objective: To correlate disease duration in spinocerebellar ataxia type 2 (SCA2) with disease severity, balance and functionality. Method: Sixteen SCA2 patients were analyzed for: disease duration, disease severity (SARA score), balance (Berg balance scale score) and functionality (FIM and Lawton scores). Results: Greater severity was correlated with worse functionality (Lawton: r = −0.0561, FIM: r = −0.6402) and balance (r = −0.7188). Longer disease duration was correlated with greater severity (p = 0.0002) and reduced functionality (FIM: p = 0.005; Lawton: p = 0.0402) and balance (p = 0.0036). A year increase in disease duration corresponded to a 0.8-point increase on the SARA scale, a 1.38-point decrease in FIM score, a 2.30-point decrease on the Berg balance scale and a 0.45-point decrease on the Lawton scale. Conclusion: Longer disease duration in this series of SCA2 patients was correlated with greater disease severity, worse balance and greater functional dependency.</p></div>