10.6084/m9.figshare.5695729.v1
Thiago R. Padilha Amarante
Thiago R. Padilha
Amarante
Sibele Y. M. Takeda
Sibele Y. M.
Takeda
Hélio A. G. Teive
Hélio
A. G. Teive
Marise Bueno Zonta
Marise Bueno
Zonta
Impact of disease duration on functional status of patients with spinocerebellar ataxia type 2
SciELO journals
2017
spinocerebellar ataxias
severity of illness index
postural balance
2017-12-13 02:40:17
Dataset
https://scielo.figshare.com/articles/dataset/Impact_of_disease_duration_on_functional_status_of_patients_with_spinocerebellar_ataxia_type_2/5695729
<div><p>ABSTRACT Objective: To correlate disease duration in spinocerebellar ataxia type 2 (SCA2) with disease severity, balance and functionality. Method: Sixteen SCA2 patients were analyzed for: disease duration, disease severity (SARA score), balance (Berg balance scale score) and functionality (FIM and Lawton scores). Results: Greater severity was correlated with worse functionality (Lawton: r = −0.0561, FIM: r = −0.6402) and balance (r = −0.7188). Longer disease duration was correlated with greater severity (p = 0.0002) and reduced functionality (FIM: p = 0.005; Lawton: p = 0.0402) and balance (p = 0.0036). A year increase in disease duration corresponded to a 0.8-point increase on the SARA scale, a 1.38-point decrease in FIM score, a 2.30-point decrease on the Berg balance scale and a 0.45-point decrease on the Lawton scale. Conclusion: Longer disease duration in this series of SCA2 patients was correlated with greater disease severity, worse balance and greater functional dependency.</p></div>