Chemical characterisation of the constituents of <i>Eugenia protenta</i> McVaugh and leishmanicidal activity of dimethylxanthoxylin
Flávio N. Sarges
Márcia M. Cascaes
Lienne S. Moraes
Giselle M. S. P. Guilhon
Edilene O. Silva
Maria das Graças B. Zoghbi
Eloisa H. A. Andrade
Ana Paula D. Rodrigues
Brenda F. Costa
Rayssa N. M. Figueiredo
10.6084/m9.figshare.5677822.v1
https://tandf.figshare.com/articles/journal_contribution/Chemical_characterisation_of_the_constituents_of_i_Eugenia_protenta_i_McVaugh_and_leishmanicidal_activity_of_dimethylxanthoxylin/5677822
<p>The chemical study of <i>Eugenia protenta</i> McVaugh extracts performed by classical and high-performance liquid chromatography techniques and spectral methods has led to the identification of known triterpenoids, flavonoids and an acetophenone derivative (dimethylxanthoxylin). The effect of dimethylxanthoxylin on <i>Leishmania</i> (<i>Leishmania</i>) <i>amazonensis</i> was evaluated against the promastigotes forms after 96 h of treatment. Dimethylxanthoxylin reduced 57 and 59% of the promastigotes growth when treated with 50 and 100 μg/mL solutions, respectively (IC<sub>50</sub> 117.35 μg/mL or 52.3 μM). Cytotoxicity experiments using MTT assays showed that this substance did not promote cell death after 24 h of treatment. Dimethylxanthoxylin was active on the promastigotes and could be a promising agent for treating leishmaniasis.</p>
2017-12-07 05:04:42
Myrtaceae
triterpenoids
flavonols
dihydroflavonol
tannin
dimethylxanthoxylin
Leishmania (L.) amazonensis