Association of Fine Motor Loss and Allodynia in Fibromyalgia: An fNIRS Study Aykut Eken Didem Gökçay Cemre Yılmaz Bora Baskak Ayşegül Baltacı Murat Kara 10.6084/m9.figshare.5674978.v1 https://tandf.figshare.com/articles/dataset/Association_of_Fine_Motor_Loss_and_Allodynia_in_Fibromyalgia_An_fNIRS_Study/5674978 <p>Recent studies showed that fine motor control dysfunction was observed in fibromyalgia (FM) syndrome as well as allodynia. However, brain signatures of this association still remain unclear. In this study, finger tapping task (FTT) and median nerve stimulation (MNS) were applied to both hands of 15 FM patients and healthy controls (HC) to understand this relationship. Hemodynamic activity was measured simultaneously using functional near-infrared spectroscopy (fNIRS). Experiments were analyzed separately by using 2x2 repeated measures ANOVA. Results for the FTT experiment revealed that HC showed higher activity than FM patients in bilateral superior parietal gyrus (SPG), left supramarginal gyrus (SMG) and right somatosensory cortex (SI). Furthermore, right-hand FTT resulted in higher activity than left-hand FTT in left SPG, left SI and right motor cortex (MI). In the MNS experiment, FM patients showed higher activity than HC in bilateral SPG, right SMG, right SI and right middle frontal gyrus (MFG). Negative correlation was observed in left SPG between FTT and MNS activities. Besides, MNS activity in left SPG was negatively correlated with left-hand pain threshold.This study revealed that left SPG might be an important indicator to associate fine motor loss and allodynia in FM.</p> 2017-12-06 14:24:14 fNIRS Fibromyalgia Fine Motor Loss