TY - DATA T1 - Ruthenium Complex Improves the Endothelial Function in Aortic Rings From Hypertensive Rats PY - 2017/12/05 AU - Izabela Pereira Vatanabe AU - Carla Nascimento dos Santos Rodrigues AU - Tereza Cristina Buzinari AU - Thiago Francisco de Moraes AU - Roberto Santana da Silva AU - Gerson Jhonatan Rodrigues UR - https://scielo.figshare.com/articles/dataset/Ruthenium_Complex_Improves_the_Endothelial_Function_in_Aortic_Rings_From_Hypertensive_Rats/5671453 DO - 10.6084/m9.figshare.5671453.v1 L4 - https://ndownloader.figshare.com/files/9916579 L4 - https://ndownloader.figshare.com/files/9916582 L4 - https://ndownloader.figshare.com/files/9916585 L4 - https://ndownloader.figshare.com/files/9916588 L4 - https://ndownloader.figshare.com/files/9916591 L4 - https://ndownloader.figshare.com/files/9916594 L4 - https://ndownloader.figshare.com/files/9916597 L4 - https://ndownloader.figshare.com/files/9916600 L4 - https://ndownloader.figshare.com/files/9916603 KW - Rats KW - Hypertension, Renal KW - Ruthenium KW - Endothelium / physiopathology KW - Nitric Oxide N2 - Abstract Background: The endothelium is a monolayer of cells that extends on the vascular inner surface, responsible for the modulation of vascular tone. By means of the release of nitric oxide (NO), the endothelium has an important protective function against cardiovascular diseases. Objective: Verify if cis- [Ru(bpy)2(NO2)(NO)](PF6)2 (BPY) improves endothelial function and the sensibility of conductance (aorta) and resistance (coronary) to vascular relaxation induced by BPY. Methods: Normotensive (2K) and hypertensive (2K-1C) Wistar rats were used. For vascular reactivity study, thoracic aortas were isolated, rings with intact endothelium were incubated with: BPY(0.01 to10 µM) and concentration effect curves to acetylcholine were performed. In addition, cumulative concentration curves were performed to BPY (1.0 nM to 0.1 µM) in aortic and coronary rings, with intact and denuded endothelium. Results: In aorta from 2K-1C animals, the treatment with BPY 0.1µM increased the potency of acetylcholine-induced relaxation and it was able to revert the endothelial dysfunction. The presence of the endothelium did not modify the effect of BPY in inducing the relaxation in aortas from 2K and 2K-1C rats. In coronary, the endothelium potentiated the vasodilator effect of BPY in vessels from 2K and 2K-1C rats. Conclusion: Our results suggest that 0.1 µM of BPY is able to normalize the relaxation endothelium dependent in hypertensive rats, and the compound BPY induces relaxation in aortic from normotensive and hypertensive rats with the same potency. The endothelium potentiate the relaxation effect induced by BPY in coronary from normotensive and hypertensive rats, with lower effect on coronary from hypertensive rats. ER -