%0 Generic %A Abuodeh, Yazan A. %A O. Naghavi, Arash %A Juan, Tzu-Hua %A Ma, Zhenjun %A Wilder, Richard B. %D 2017 %T Quality of Life after post-prostatectomy intensity modulated radiation therapy to the prostate bed with or without the use of gold fiducial markers for image guidance or higher total radiotherapy doses %U https://scielo.figshare.com/articles/dataset/Quality_of_Life_after_post-prostatectomy_intensity_modulated_radiation_therapy_to_the_prostate_bed_with_or_without_the_use_of_gold_fiducial_markers_for_image_guidance_or_higher_total_radiotherapy_doses/5670577 %R 10.6084/m9.figshare.5670577.v1 %2 https://ndownloader.figshare.com/files/9912244 %2 https://ndownloader.figshare.com/files/9912247 %2 https://ndownloader.figshare.com/files/9912250 %2 https://ndownloader.figshare.com/files/9912253 %2 https://ndownloader.figshare.com/files/9912256 %K Prostate %K Postoperative Care %K Radiotherapy %K Quality of Life %X

ABSTRACT Purpose To evaluate quality of life (QoL) after post-prostatectomy intensity modulated radiation therapy (IMRT) in the “adjuvant” setting starting within 4 months of radical prostatectomy for adverse features; and “salvage” setting for a PSA≥0.2ng/mL. Materials and Methods Retrospective review of 130 patients who underwent IMRT to the prostate bed±gold fiducial marker placement for image guidance to 64.8-72.0Gy (median, 70.2Gy) between 2004 and 2013. Higher doses were defined as 70.2-72.0Gy and lower doses were defined as 64.8-68.4Gy. Androgen deprivation therapy (ADT) was given to 4/48 (8%) adjuvant patients and 9/82 (11%) salvage patients. International Prostate Symptom Score (IPSS), Sexual Health Inventory for Men (SHIM), and Expanded Prostate Cancer Index Composite-26-bowel (EPIC-26-bowel) questionnaires were used to assess urinary, sexual, and bowel QoL, respectively. Results Median follow-up was 46 months. There were better urinary (p=0.03) and sexual (p=0.002) QoL scores with adjuvant IMRT relative to salvage IMRT. The use of prostate bed fiducial markers did not significantly affect urinary, sexual, or bowel QoL (p=0.39, p=0.49, and p=0.40, respectively). Higher total radiotherapy doses did not significantly affect urinary, sexual, or bowel QoL (p=0.21, p=0.61, and p=0.36, respectively). Conclusions There was no significant change in urinary, sexual, and bowel sexual QoL with post-prostatectomy IMRT regardless of whether prostate bed fiducial markers or higher total radiotherapy doses were used. QoL with IMRT in the present study compares favorably with prior reports for three-dimensional conformal radiation therapy.

%I SciELO journals