10.6084/m9.figshare.5669023.v1
Isabelle Oliveira Jatai Capelo
Isabelle Oliveira Jatai
Capelo
Avner Marcos Alves Batista
Avner Marcos Alves
Batista
Yuri Neyson Ferreira Brito
Yuri Neyson Ferreira
Brito
Krissia Braga Diniz
Krissia Braga
Diniz
Gerly Anne de Castro Brito
Gerly
Anne de Castro Brito
Marcos Rabelo de Freitas
Marcos Rabelo de
Freitas
Study of the protective effect of dexamethasone on cisplatin-induced ototoxicity in rats
SciELO journals
2017
Dexamethasone
Cisplatin
Rats
2017-12-05 09:55:33
Dataset
https://scielo.figshare.com/articles/dataset/Study_of_the_protective_effect_of_dexamethasone_on_cisplatin-induced_ototoxicity_in_rats/5669023
<div><p>Abstract Purpose: To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity. Methods: Male Wistar rats were divided into the following three groups: 1) Control (C): 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP: 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for four days; and 3) DEXA15 + CDDP: 11 animals received IP dexamethasone 15 mg/kg/day and, 90 min after dexamethasone administration, received 8 mg/kg/day of IP CDDP for four days. Results: It was found that dexamethasone did not protect against weight loss in CDDP-exposed animals. The mortality rate was comparable with that previously reported in the literature. The auditory threshold of animals in the DEXA15 + CDDP group was not significantly altered after exposure to CDDP. The stria vascularis of animals in the DEXA15 + CDDP group was partially preserved after CDDP exposure. Conclusions: Dexamethasone at the dose of 15 mg/kg/day partially protected against CDDP-induced ototoxicity, based on functional evaluation by brainstem evoked response audiontry (BERA) and morphological evaluation by optical microscopy. However, dexamethasone did not protect against systemic toxicity.</p></div>