TY - DATA T1 - Use of HAS-BLED Score in an Anticoagulation Outpatient Clinic of a Tertiary Hospital PY - 2017/12/05 AU - Rafael Coimbra Ferreira Beltrame AU - Franciele Taís Bandeira Giasson AU - André Luís Ferreira Azeredo da Silva AU - Bruna Sessim Gomes AU - Luís Carlos Amon AU - Marina Bergamini Blaya AU - Rafael Selbach Scheffel AU - Fernando Pivatto Júnior UR - https://scielo.figshare.com/articles/dataset/Use_of_HAS-BLED_Score_in_an_Anticoagulation_Outpatient_Clinic_of_a_Tertiary_Hospital/5668669 DO - 10.6084/m9.figshare.5668669.v1 L4 - https://ndownloader.figshare.com/files/9903295 L4 - https://ndownloader.figshare.com/files/9903301 L4 - https://ndownloader.figshare.com/files/9903310 L4 - https://ndownloader.figshare.com/files/9903316 L4 - https://ndownloader.figshare.com/files/9903328 L4 - https://ndownloader.figshare.com/files/9903343 L4 - https://ndownloader.figshare.com/files/9903352 KW - Atrial Fibrillation KW - Hemorrhage KW - Outpatient Clinics KW - Hospital N2 - Abstract Background: HAS-BLED score was developed to assess 1-year major bleeding risk in patients anticoagulated with vitamin K antagonists (VKA) due to atrial fibrillation (AF). Objective: Of this study was to assess the ability of HAS-BLED score and its components to predict major bleeding in patients treated in an anticoagulation outpatient clinic of a tertiary hospital. Methods: A retrospective cohort study on AF patients treated with VKA was conducted. Logistic regression analysis was performed to evaluate the ability of individual score components to predict major bleeding. The significance level adopted in all tests was 5%. Results: We studied 263 patients with a mean age of 71.1 ± 10.5 years over a period of 237.6 patients-year. Median HAS-BLED score was 2 (1-3). The overall incidence of major bleeding was 5.7%, and it was higher among high-risk HAS-BLED score patients than in low risk patients (9.6 vs. 3.1%; p = 0.052). Area under the ROC curve was 0.70 (p = 0.01). Cut-off point ≥ 3 showed sensibility of 66.7%, specificity of 62.1%, positive predictive value of 9.6% and negative predictive value of 96.9%. Major bleeding-free survival was lower in high-risk group (p = 0.017). In multivariate analysis, concurrent antiplatelet use was the only independent predictor of major bleeding among score components (OR 5.13, 95%CI: 1.55-17.0; p = 0.007). Conclusion: HAS-BLED score was able to predict major bleeding in this cohort of AF patients. Among score components, special attention should be given for concomitant antiplatelet use, which was independently associated to this outcome. Antiplatelets in AF patients under VKA anticoagulation should be used in selected patients with favorable risk-benefit assessment. ER -