10.6084/m9.figshare.5668522.v1
Lilian Cristina Gomes Cavalcanti
Lilian Cristina Gomes
Cavalcanti
José Carlos Ferrugem Moraes
José Carlos Ferrugem
Moraes
Danielle Assis de Faria
Danielle Assis de
Faria
Concepta Margaret McManus
Concepta Margaret
McManus
Alcebiades Renato Nepomuceno
Alcebiades Renato
Nepomuceno
Carlos José Hoff de Souza
Carlos José Hoff de
Souza
Alexandre Rodrigues Caetano
Alexandre
Rodrigues Caetano
Samuel Rezende Paiva
Samuel
Rezende Paiva
Genetic characterization of coat color genes in Brazilian Crioula sheep from a conservation nucleus
SciELO journals
2017
Ovis aris
ASIP
genetic resources conservation
marker-assisted selection
MC1R
TYRP1
2017-12-05 09:35:30
Dataset
https://scielo.figshare.com/articles/dataset/Genetic_characterization_of_coat_color_genes_in_Brazilian_Crioula_sheep_from_a_conservation_nucleus/5668522
<div><p>Abstract: The objective of this work was to identify single nucleotide polymorphisms (SNPs) in resequencing data from MC1R, ASIP, and TYRP1 genes derived from Crioula sheep (Ovis aris) with different coat colors. Polymorphisms in the ASIP (agouti-signaling protein), MC1R (melanocortin 1 receptor), and TRYP1 (tyrosinase-related protein 1) genes were analyzed in 115 sheep from Embrapa’s conservation nucleus of crioula sheep, in Brazil. A total of 7,914 bp were sequenced per animal, and 14 SNPs were identified. Two additional assays were performed to detect duplications and deletions in the ASIP gene. Ninety-five percent of the coat color variation was explained by epistatic interactions observed between specific alleles in the MC1R and ASIP genes. Evidence suggests an important role of TYRP1 variants for wool color, despite their low frequencies. The marker panel was efficient enough in predicting coat color in the studied animals and, therefore, can be used to implement a marker-assisted selection program in the conservation nucleus of sheep of the crioula breed.</p></div>