10.6084/m9.figshare.5668369.v1
Ana Luiza Peretti
Ana Luiza
Peretti
Juliana Sobral Antunes
Juliana Sobral
Antunes
Keli Lovison
Keli
Lovison
Regina Inês Kunz
Regina Inês
Kunz
Lidyane Regina Gomes Castor
Lidyane Regina Gomes
Castor
Rose Meire Costa Brancalhão
Rose Meire Costa
Brancalhão
Gladson Ricardo Flor Bertolini
Gladson Ricardo Flor
Bertolini
Lucinéia de Fátima Chasko Ribeiro
Lucinéia
de Fátima Chasko Ribeiro
Action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after nerve injury
SciELO journals
2017
Muscle, skeletal
Muscle denervation
Peripheral nerve injuries
Rehabilitation
Biological products
2017-12-05 09:33:22
Dataset
https://scielo.figshare.com/articles/dataset/Action_of_vanillin_Vanilla_planifolia_on_the_morphology_of_tibialis_anterior_and_soleus_muscles_after_nerve_injury/5668369
<div><p>ABSTRACT Objective To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by compression of the sciatic nerve; the Vanillin Group and Injury + Vanillin Group, were treated daily with oral doses of vanillin (150mg/kg) from the 3rd to the 21st day after induction of nerve injury. At the end of the experiment, the tibialis anterior and soleus muscles were dissected and processed for light microscopy and submitted to morphological analysis. Results The nerve compression promoted morphological changes, typical of denervation, and the treatment with vanillin was responsible for different responses in the studied muscles. For the tibialis anterior, there was an increase in the number of satellite cells, central nuclei and fiber atrophy, as well as fascicular disorganization. In the soleus, only increased vascularization was observed, with no exacerbation of the morphological alterations in the fibers. Conclusion The treatment with vanillin promoted increase in intramuscular vascularization for the muscles studied, with pro-inflammatory potential for tibialis anterior, but not for soleus muscle.</p></div>