10.6084/m9.figshare.5666191.v1
Audrius Dulskas
Audrius
Dulskas
Mahdi Al Bandar
Al
Bandar
Yoon Young Choi
Yoon
Young Choi
Su-Jin Shin
Su-Jin
Shin
Seung-Hoon Beom
Seung-Hoon
Beom
Taeil Son
Taeil
Son
Hyung-Il Kim
Hyung-Il
Kim
Jae-Ho Cheong
Jae-Ho
Cheong
Woo Jin Hyung
Woo
Jin Hyung
Sung Hoon Noh
Sung Hoon
Noh
A case of gastric cancer metastasis to the breast in a female with <i>BRCA2</i> germline mutation and literature review
Taylor & Francis Group
2017
Gastric cancer
BRCA2
breast metastasis
2017-12-05 08:30:58
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/A_case_of_gastric_cancer_metastasis_to_the_breast_in_a_female_with_i_BRCA2_i_germline_mutation_and_literature_review/5666191
<p><b>Introduction:</b> Gastric cancer is a deadly disease. Common sites of distant metastasis of gastric cancer are the peritoneum, liver, lymph nodes, and lung. The breast is a rare site of metastasis in gastric cancer which occurs in males dominantly.</p> <p><b>Patients and methods:</b> Here, we report the first case of metastatic gastric cancer to the breast in a patient with the breast cancer 2 (<i>BRCA2)</i> germline mutation. A 34-year-old female was admitted to the hospital with dyspepsia and a palpable mass in the left breast. Gastric cancer was confirmed to be signet ring cell adenocarcinoma. The breast mass exhibited histological properties consistent with gastric cancer. Immunohistochemistry results showed the breast tumor was CDX-2 and CK20-positive, but ER-, CK7-, and GATA3-negative. The <i>BRCA1</i> gene had a wild-type sequence, but a heterozygous variant was discovered in <i>BRCA2</i> in exon 10 (c.1744A > C, p.T582P); the significance of this variant is unknown.</p> <p><b>Results:</b> The patient received palliative XELOX (capecitabine + oxaliplatin) with radiation therapy to the stomach. The breast tumor resolved completely, but the overall response was partial.</p> <p><b>Conclusion:</b> Gastric cancer metastasis to the breast is rare, but should be considered in young female patients with signet ring cell type gastric cancer.</p>