TY - DATA T1 - Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A PY - 2017/12/04 AU - Abdul-Malek S. Altamimi AU - Ahmed M. Alafeefy AU - Agnese Balode AU - Igor Vozny AU - Aleksandrs Pustenko AU - Mohey Eldin El Shikh AU - Fatmah A. S. Alasmary AU - Sherif A. Abdel-Gawad AU - Raivis Žalubovskis UR - https://tandf.figshare.com/articles/journal_contribution/Symmetric_molecules_with_1_4-triazole_moieties_as_potent_inhibitors_of_tumour-associated_lactate_dehydrogenase-A/5662360 DO - 10.6084/m9.figshare.5662360.v1 L4 - https://ndownloader.figshare.com/files/9880327 KW - Lactate dehydrogenase KW - triazole KW - inhibitors N2 - A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC50 = 117–174 µM. Seven compounds exhibited better LDHA inhibition (IC50 117–136 µM) compared to known LDH inhibitor – galloflavin (IC50 157 µM). ER -