Cost-effectiveness analysis of infliximab, adalimumab, golimumab and vedolizumab for moderate to severe ulcerative colitis in Spain Cristina Trigo-Vicente Vicente Gimeno-Ballester Raquel Montoiro-Allué Alejandro López-Del Val 10.6084/m9.figshare.5658919.v2 https://tandf.figshare.com/articles/journal_contribution/Cost-effectiveness_analysis_of_infliximab_adalimumab_golimumab_and_vedolizumab_for_moderate_to_severe_ulcerative_colitis_in_Spain/5658919 <p><b>Objectives</b>: Assess the efficiency of biologic treatment for moderate to severe ulcerative colitis (UC) which are indicated and financed for this pathology by Spain.</p> <p><b>Methods</b>: A Markov model was constructed to simulate the progression in a cohort of patients with moderate to severe UC. The perspective chosen was National Health Service with an over 10 years of time horizon, with a discount rate of 3%, and established threshold of €30,000/quality-adjusted life-year (QALY).</p> <p><b>Results</b>: The comparison between infliximab versus adalimumab achieved an incremental cost-effectiveness ratio (ICER) of €45,582/QALY, with a 0.900 QALYs difference of efficacy and an incremental cost of €41,036. Golimumab versus adalimumab reached an ICER of €2,175,992/QALY, with a difference of 0.001 QALY in efficacy and a raising cost to €2,611. The comparison between vedolizumab with adalimumab achieved an ICER of €90,532/QALY, 0.930 QALYs of difference and an increasing cost of €84,218. The probabilistic sensitivity analysis shows that adalimumab would be cost-effective in the 65.2% of the simulations, infliximab in the 18.4%, golimumab in the 16.4% and vedulizumab for the 0%.</p> <p><b>Conclusions</b>: Among all these drugs studied, adalimumab is the most cost-effective drug for the treatment of moderate to severe UC for a threshold of €30,000/QALY in Spain.</p> 2017-12-02 11:42:06 Ulcerative colitis infliximab adalimumab golimumab vedolizumab cost-effectiveness analysis Markov model