10.6084/m9.figshare.5644732.v1
Taiane Berguemaier de Lima
Taiane Berguemaier de
Lima
Isadora Peres Klein
Isadora Peres
Klein
Márcia Gaiger de Oliveira
Márcia Gaiger de
Oliveira
Pantelis Varvaki Rados
Pantelis Varvaki
Rados
Manoel Sant’Ana Filho
Manoel Sant’Ana
Filho
Fernanda Visioli
Fernanda
Visioli
Analysis of the Epithelium-Mesenchymal Transition Process on Oral Squamous Cell Carcinomas
SciELO journals
2017
oral cancer
prognosis
E-cadherin
N-cadherin
Bmi-1.
2017-11-29 12:10:45
Dataset
https://scielo.figshare.com/articles/dataset/Analysis_of_the_Epithelium-Mesenchymal_Transition_Process_on_Oral_Squamous_Cell_Carcinomas/5644732
<div><p>Abstract The aim of this study is to evaluate the immunohistochemical expression of E-cadherin, N-cadherin and Bmi-1, and their association with clinical parameters and with the degree of histopathological differentiation in oral squamous cell carcinomas. 65 squamous cell carcinoma samples were used for constructing a tissue microarray block, and then immunohistochemistry was performed for different markers. A semi-quantitative analysis of the amount of positive tumor cells was performed by two blind and calibrated observers (Kappa>0.75). The statistical Mann-Whitney and Kruskal-Wallis tests were used to evaluate the data. The correlation between variables was investigated by the Spearman test, and the significance level set at p<0.05. We observed higher expression of Bmi-1 in tumors located in the palate (p<0.0001). In addition, poorly differentiated tumors had a greater amount of Bmi-1 positive cells (p=0.0011). Regarding the other correlations between variables, no significant associations were detected. In conclusion, poorly differentiated squamous cell carcinomas located in the palate have higher immunostaining of Bmi-1, which can characterize activation of the Epithelial-Mesenchymal Transition process in these tumors.</p></div>