10.6084/m9.figshare.5644732.v1 Taiane Berguemaier de Lima Taiane Berguemaier de Lima Isadora Peres Klein Isadora Peres Klein Márcia Gaiger de Oliveira Márcia Gaiger de Oliveira Pantelis Varvaki Rados Pantelis Varvaki Rados Manoel Sant’Ana Filho Manoel Sant’Ana Filho Fernanda Visioli Fernanda Visioli Analysis of the Epithelium-Mesenchymal Transition Process on Oral Squamous Cell Carcinomas SciELO journals 2017 oral cancer prognosis E-cadherin N-cadherin Bmi-1. 2017-11-29 12:10:45 Dataset https://scielo.figshare.com/articles/dataset/Analysis_of_the_Epithelium-Mesenchymal_Transition_Process_on_Oral_Squamous_Cell_Carcinomas/5644732 <div><p>Abstract The aim of this study is to evaluate the immunohistochemical expression of E-cadherin, N-cadherin and Bmi-1, and their association with clinical parameters and with the degree of histopathological differentiation in oral squamous cell carcinomas. 65 squamous cell carcinoma samples were used for constructing a tissue microarray block, and then immunohistochemistry was performed for different markers. A semi-quantitative analysis of the amount of positive tumor cells was performed by two blind and calibrated observers (Kappa>0.75). The statistical Mann-Whitney and Kruskal-Wallis tests were used to evaluate the data. The correlation between variables was investigated by the Spearman test, and the significance level set at p<0.05. We observed higher expression of Bmi-1 in tumors located in the palate (p<0.0001). In addition, poorly differentiated tumors had a greater amount of Bmi-1 positive cells (p=0.0011). Regarding the other correlations between variables, no significant associations were detected. In conclusion, poorly differentiated squamous cell carcinomas located in the palate have higher immunostaining of Bmi-1, which can characterize activation of the Epithelial-Mesenchymal Transition process in these tumors.</p></div>